Function of the adrenal cortex in obese-hyperglycemic mice (gene symbolob)

Hereditary Obese-Hyperglycemic Syndrome of Mice *

The metabolic characteristics of a new Mendelian recessive syndrome in mice have been described in previous publications. The condition is characterized by an adult body weight of 50-100 g. instead of a normal 20-30 g., sterility,'0 hyperglycemia and glycosuria,'7 atrophic changes and ulceration of the skin, and decreased life span. Histopathological studies reveal enlarged islets of Langerhans...

Imperfect homeothermia in the hereditary obese-hyperglycemic syndrome of mice.

‏‎interpersonal function of language in subtitling

‏‎translation as a comunicative process is always said to be associated with various aspects of meaning loss or gain. subtitling as a mode of translating, due to special discoursal and textual conditions imposed upon it, is believed to be an obvious case of this loss or gain. presenting the spoken sound track of a film in writing and synchronizing the perception of this text by the viewers with...

Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice.

The genetically obese-hyperglycemic mouse, C57 BL/6J-ob, exhibits hyperglycemia and hyperinsulinemia. We have investigated the in vivo hepatic response to a glucose load in female obese mice and their lean littermates. Within 15 min after the administration of glucose (1.5 g/kg) to fasted lean mice, gluconeogenesis from [14C]alanine markedly decreased, endogenous hepatic levels of alanine and o...

Non-Invasive Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice

BACKGROUND Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previous studies have shown a correlation between β-cell function and bioluminescent imaging in lean genetically engineered mice. The ability to noninvasi...